' 
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.4
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**
Maitake Mushroom Extract standardized to 30% pure D-fraction (9 mg)
30 mg
**
Cat's Claw Extract (bark) standardized to 4% alkaloids (0.4 mg)
10 mg
**
Top Medical Research Studies
9
Maitake mushrooms reduce cholesterol levels
Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats.
Direct evaluation of cholesterol effects
We explored how polysaccharides derived from maitake mushrooms, known scientifically as Grifola frondosa, can influence high cholesterol and other lipid issues. This study focused on rats fed a high-fat diet, a common model for examining metabolic disorders.
By administering these mushroom polysaccharides, we observed a remarkable decrease in levels of total triglycerides, cholesterol, and free fatty acids in the rats' blood. Additionally, liver fat accumulation was notably reduced, highlighting the potential of maitake mushrooms to combat fat buildup in the body.
Furthermore, we noted an increase in bile acid excretion among the rats receiving the mushroom treatment. This finding suggests that maitake may help improve cholesterol processing by promoting the removal of fats from the liver.
The research also identified changes in the gut microbiota among the treated rats, as certain beneficial bacteria flourished while harmful ones declined. This shift aligns with improved lipid metabolism, hinting at a complex relationship between our gut health and cholesterol levels.
It was evident that the consumption of maitake mushrooms could lead to positive changes in lipid profiles, making them an appealing option for those seeking natural ways to manage cholesterol and prevent hyperlipidemia.
By administering these mushroom polysaccharides, we observed a remarkable decrease in levels of total triglycerides, cholesterol, and free fatty acids in the rats' blood. Additionally, liver fat accumulation was notably reduced, highlighting the potential of maitake mushrooms to combat fat buildup in the body.
Furthermore, we noted an increase in bile acid excretion among the rats receiving the mushroom treatment. This finding suggests that maitake may help improve cholesterol processing by promoting the removal of fats from the liver.
The research also identified changes in the gut microbiota among the treated rats, as certain beneficial bacteria flourished while harmful ones declined. This shift aligns with improved lipid metabolism, hinting at a complex relationship between our gut health and cholesterol levels.
It was evident that the consumption of maitake mushrooms could lead to positive changes in lipid profiles, making them an appealing option for those seeking natural ways to manage cholesterol and prevent hyperlipidemia.
Read More
9
Maitake mushroom lowers cholesterol levels
The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats.
Strong relevance to cholesterol treatment
We examined the effects of Grifola frondosa, commonly known as maitake mushroom, on cholesterol levels, particularly in rats with high cholesterol diets. In our study, we looked at how this mushroom could potentially influence lipid metabolism in the liver.
Our results showed that rats treated with maitake mushroom experienced significant reductions in serum cholesterol, triglycerides, and LDL cholesterol compared to those who didn't receive treatment. We noticed a decrease in the expression of key enzymes that are crucial for cholesterol and fat production, suggesting that maitake helps regulate lipid levels effectively.
Furthermore, we utilized advanced techniques to identify proteins expressed differently in the livers of treated versus untreated rats. The findings indicate that the maitake mushroom not only lowers cholesterol levels but may also help reduce the risk of atherosclerosis by inhibiting LDL oxidation.
Overall, these insights suggest that making maitake mushroom a functional food could be worthwhile for managing high cholesterol and promoting heart health.
Our results showed that rats treated with maitake mushroom experienced significant reductions in serum cholesterol, triglycerides, and LDL cholesterol compared to those who didn't receive treatment. We noticed a decrease in the expression of key enzymes that are crucial for cholesterol and fat production, suggesting that maitake helps regulate lipid levels effectively.
Furthermore, we utilized advanced techniques to identify proteins expressed differently in the livers of treated versus untreated rats. The findings indicate that the maitake mushroom not only lowers cholesterol levels but may also help reduce the risk of atherosclerosis by inhibiting LDL oxidation.
Overall, these insights suggest that making maitake mushroom a functional food could be worthwhile for managing high cholesterol and promoting heart health.
Read More
9
Maitake mushrooms reduce cholesterol
Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I.
Strong evidence for lipid benefits
We investigated the effects of maitake mushrooms on high cholesterol levels in rats, using experimental models specifically designed to simulate hyperlipemia. The rats were given a diet rich in cholesterol, supplemented with sodium cholate and casein as a protein source, to trigger high cholesterol levels.
When we added dried maitake mushroom powder to their diet, we observed significant reductions in serum lipids, including cholesterol and triglycerides. In fact, the cholesterol levels dropped to about 30-70% of those in rats fed just the high-cholesterol diet. This indicates that maitake may help manage cholesterol effectively.
Furthermore, we noticed that the high levels of "good" HDL cholesterol typically reduced by high-cholesterol diets remained stable in the maitake-fed group. We also found that liver weights and fat pads were significantly lower in these rats, which suggests that maitake could reduce fat accumulation in the body. Additionally, the inclusion of maitake in their diet enhanced cholesterol and bile acid excretion, which may further support improved lipid metabolism.
Overall, our findings suggest that maitake mushrooms may offer a natural way to combat elevated cholesterol levels and promote better health when included as part of a balanced diet.
When we added dried maitake mushroom powder to their diet, we observed significant reductions in serum lipids, including cholesterol and triglycerides. In fact, the cholesterol levels dropped to about 30-70% of those in rats fed just the high-cholesterol diet. This indicates that maitake may help manage cholesterol effectively.
Furthermore, we noticed that the high levels of "good" HDL cholesterol typically reduced by high-cholesterol diets remained stable in the maitake-fed group. We also found that liver weights and fat pads were significantly lower in these rats, which suggests that maitake could reduce fat accumulation in the body. Additionally, the inclusion of maitake in their diet enhanced cholesterol and bile acid excretion, which may further support improved lipid metabolism.
Overall, our findings suggest that maitake mushrooms may offer a natural way to combat elevated cholesterol levels and promote better health when included as part of a balanced diet.
Read More
Most Useful Reviews
8
Effective treatment
I believe that Nature's Way products are more effective than IP6 Gold. This is my second review of IP6 products; I have previously used Nature's Way. High ferritin is quite troubling for me, as it once exceeded 800 and I also have fatty liver. Despite trying numerous liver-protecting products and exercising, I had little success. I read on Xiaohongshu about someone whose ferritin normalised after eight months on this product, which inspired me to try it. Initially, my ferritin was 791.55, but after two months of using Nature's Way, it reduced to 657.69. I am pleased with the results and my determination to continue has strengthened. Additionally, my liver function tests improved significantly. After switching to IP6 Gold, my ferritin dropped to 604.91 after three months, but the decline has slowed. I intend to return to Nature's Way for another three months for comparison.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.4
- All Researches
9
Inositol boosts growth and health
Inositol Inclusion Affects Growth, Body Composition, Antioxidant Performance, and Lipid Metabolism of Largemouth Bass ().
Mixed effects on cholesterol levels
We explored how inositol affects growth performance and cholesterol levels in largemouth bass through a systematic diet study. By preparing six different diets with varying inositol concentrations, we fed the fish for eight weeks and closely monitored their progress. The results showed that our group consuming 250 mg/kg of inositol enjoyed significantly better weight gain, growth rates, and feed efficiency compared to the control group.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Interestingly, as we increased the inositol levels, we noticed a rise in serum triglycerides and cholesterol, particularly peaking in the 250 mg/kg group. It appeared that while inositol helped improve overall growth, it also influenced cholesterol levels in a complex way. However, the high-density lipoprotein cholesterol (HDL-C), often considered "good" cholesterol, remained unaffected across all treatment groups.
Furthermore, our analysis revealed that inositol supplementation not only reduced fat deposition in the liver but also enhanced the fish's antioxidant capacity by lowering harmful enzymes and increasing beneficial antioxidant markers. This suggests that while inositol modified cholesterol dynamics, it also supported the general health and performance of the fish.
Overall, the findings indicate that dietary inositol can significantly improve growth and antioxidant capacity in largemouth bass, with an optimal dosage around 250 mg/kg to harness these benefits effectively.
Read More
9
Food supplement aids cholesterol management
Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Blume and Inulin in Patients with Metabolic Syndrome.
Inositol's isolated effects unclear
We tested the effectiveness of a food supplement combining glucomannan, D-chiro-inositol, blume, and inulin in managing high cholesterol levels among individuals with metabolic syndrome. Fifty-eight participants, each dealing with either type 2 diabetes or impaired glucose tolerance, took this supplement daily for four months alongside their metformin medication.
Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).
Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
Over the course of the study, we observed significant improvements in several key health markers. The participants experienced a marked reduction in their body weight and body mass index (BMI). More importantly for those dealing with high cholesterol, the supplement contributed to noteworthy enhancements in their lipid profiles. Levels of total cholesterol reduced significantly, alongside improvements in triglycerides and low-density lipoprotein (LDL).
Our findings suggest that this food supplement may be a beneficial addition to traditional treatments for managing cholesterol levels and other risk factors associated with metabolic syndrome. This study highlights the potential of inositol as part of a multi-ingredient supplement, although the specific effect of inositol alone wasn't isolated.
Read More
9
D--Inositol reduces cholesterol levels
D--Inositol facilitates adiponectin biosynthesis and activates the AMPKα/PPARs pathway to inhibit high-fat diet-induced obesity and liver lipid deposition.
Study shows significant lipid impact
We examined how D--Inositol (DCI), a natural compound found in many living organisms, influences high cholesterol and obesity, especially when combined with a high-fat diet. In our study involving mice over a 12-week period, we observed that DCI supplementation led to noticeable reductions in body weight, triglycerides, total cholesterol, insulin, and fasting glucose levels when given at doses of 50 and 100 mg per kg daily.
The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.
Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
The findings were encouraging as DCI not only diminished body weight but also helped lower fat accumulation in the liver and fat tissue. Importantly, we noted a significant increase in serum adiponectin levels, a beneficial hormone linked to improved lipid metabolism. This increase was accompanied by enhanced activity of adiponectin receptors in the liver, which play a key role in regulating fat and energy metabolism.
Additionally, DCI was shown to activate a critical pathway involving AMPKα and PPARs, further promoting healthy fat management in the body. These results suggest that DCI could be a valuable ally in addressing cholesterol and obesity issues, potentially through its influence on adiponectin synthesis and its related metabolic pathways.
Read More
9
Maitake mushroom aids cholesterol management
Polysaccharides of Grifola frondosa ameliorate oxidative stress and hypercholesterolaemia in hamsters fed a high-fat, high-cholesterol diet.
Directly addresses cholesterol effects
We embarked on a study to examine how maitake mushroom, specifically Grifola frondosa, affects high cholesterol levels in hamsters on a high-fat, high-cholesterol diet. By administering various forms of the mushroom—like its fruiting bodies, fermented mycelia, and polysaccharides—we looked closely at how these treatments influenced blood lipid profiles and antioxidant status.
Our findings revealed some noteworthy benefits. The fruiting bodies of maitake significantly reduced weight gain, serum triglycerides, and cholesterol levels. Furthermore, they seemed to boost the liver's ability to produce bile acids, which are essential for cholesterol breakdown. Other forms of the mushroom, including fermented mycelia and polysaccharides, also contributed to lowering cholesterol and triglyceride levels in the blood.
We also discovered that maitake mushrooms can enhance antioxidant activity, which helps combat oxidative stress caused by high-fat diets. This improvement in redox status includes increases in crucial antioxidant compounds and decreased harmful oxidized forms of glutathione in the liver. Overall, our study suggests that adding maitake mushrooms to one’s diet may help manage hypercholesterolaemia and support liver health.
Our findings revealed some noteworthy benefits. The fruiting bodies of maitake significantly reduced weight gain, serum triglycerides, and cholesterol levels. Furthermore, they seemed to boost the liver's ability to produce bile acids, which are essential for cholesterol breakdown. Other forms of the mushroom, including fermented mycelia and polysaccharides, also contributed to lowering cholesterol and triglyceride levels in the blood.
We also discovered that maitake mushrooms can enhance antioxidant activity, which helps combat oxidative stress caused by high-fat diets. This improvement in redox status includes increases in crucial antioxidant compounds and decreased harmful oxidized forms of glutathione in the liver. Overall, our study suggests that adding maitake mushrooms to one’s diet may help manage hypercholesterolaemia and support liver health.
Read More
9
Maitake mushrooms reduce cholesterol levels
Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats.
Direct evaluation of cholesterol effects
We explored how polysaccharides derived from maitake mushrooms, known scientifically as Grifola frondosa, can influence high cholesterol and other lipid issues. This study focused on rats fed a high-fat diet, a common model for examining metabolic disorders.
By administering these mushroom polysaccharides, we observed a remarkable decrease in levels of total triglycerides, cholesterol, and free fatty acids in the rats' blood. Additionally, liver fat accumulation was notably reduced, highlighting the potential of maitake mushrooms to combat fat buildup in the body.
Furthermore, we noted an increase in bile acid excretion among the rats receiving the mushroom treatment. This finding suggests that maitake may help improve cholesterol processing by promoting the removal of fats from the liver.
The research also identified changes in the gut microbiota among the treated rats, as certain beneficial bacteria flourished while harmful ones declined. This shift aligns with improved lipid metabolism, hinting at a complex relationship between our gut health and cholesterol levels.
It was evident that the consumption of maitake mushrooms could lead to positive changes in lipid profiles, making them an appealing option for those seeking natural ways to manage cholesterol and prevent hyperlipidemia.
By administering these mushroom polysaccharides, we observed a remarkable decrease in levels of total triglycerides, cholesterol, and free fatty acids in the rats' blood. Additionally, liver fat accumulation was notably reduced, highlighting the potential of maitake mushrooms to combat fat buildup in the body.
Furthermore, we noted an increase in bile acid excretion among the rats receiving the mushroom treatment. This finding suggests that maitake may help improve cholesterol processing by promoting the removal of fats from the liver.
The research also identified changes in the gut microbiota among the treated rats, as certain beneficial bacteria flourished while harmful ones declined. This shift aligns with improved lipid metabolism, hinting at a complex relationship between our gut health and cholesterol levels.
It was evident that the consumption of maitake mushrooms could lead to positive changes in lipid profiles, making them an appealing option for those seeking natural ways to manage cholesterol and prevent hyperlipidemia.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Effective treatment
I believe that Nature's Way products are more effective than IP6 Gold. This is my second review of IP6 products; I have previously used Nature's Way. High ferritin is quite troubling for me, as it once exceeded 800 and I also have fatty liver. Despite trying numerous liver-protecting products and exercising, I had little success. I read on Xiaohongshu about someone whose ferritin normalised after eight months on this product, which inspired me to try it. Initially, my ferritin was 791.55, but after two months of using Nature's Way, it reduced to 657.69. I am pleased with the results and my determination to continue has strengthened. Additionally, my liver function tests improved significantly. After switching to IP6 Gold, my ferritin dropped to 604.91 after three months, but the decline has slowed. I intend to return to Nature's Way for another three months for comparison.
Read More
